Title | Correlation between pre-treatment growth rate and tumor control of vestibular schwannomas after gamma knife radiosurgery in the dutch database |
Publication Type | Conference Paper |
Year of Publication | 2017 |
Authors | Langenhuizen, PPJH, Zinger, S, Hanssens, P, Kunst, H, Mulder, J, Leenstra, S, de With, PHN, Verheul, HB |
Conference Name | 13th International Stereotactic Radiosurgery Society Congress |
Date Published | 10/2017 |
Publisher | Old City Publishing |
Conference Location | Montreux, Switzerland |
ISBN Number | 978-1-933153-34-6 |
Keywords | Gamma Knife radiosurgery, pre-treatment growth rate, tumor control, vestibular schwannoma, volume doubling time |
Abstract | Introduction: Prognostic factors of tumor control after Gamma Knife Radiosurgery (GKRS) for vestibular schwannoma (VS) are largely unknown. Recently, it has been reported that the growth rate of VS before treatment is indicative of the chance that radiosurgery achieves tumor control. Such findings may have important implications for treatment strategies and may lead to advise for either microsurgery or higher marginal doses for fast growing tumors. However, studies on this important aspect are limited and show conflicting results. Moreover, the available studies are hampered by methodological limitations such as limited patient numbers and followup and two-dimensional assessment of tumor size. The objective of this study is to identify a possible correlation between pre-treatment growth rate and tumor control after GKRS in a large database with sufficient follow-up and volumetric tumor assessments. |